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A study of oil of bergamot and its importance as a phototoxic agent
Author(s) -
Zaynoun S. T.,
Johnson B. E.,
FrainBell W.
Publication year - 1977
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1977.tb03667.x
Subject(s) - phototoxicity , sunscreening agents , chemistry , furocoumarins , dermatology , pharmacology , medicine , photochemistry , biochemistry , cancer , skin cancer , in vitro
Using a standardized open photopatch test technique, the phototoxic reactions produced by bergamot oil bergapten (5‐methoxypsoralen) the active component of the oil, and xantho‐toxin 8‐methoxypsoralen) were studied. The reaction was affected by a range of factors such as the vehicle (PMF or ethanol), the concentration of ethanol in the vehicle, the skin site, the interval between application of the psoralen and irradiation, the hydration of the skin, and the degree of natural or sun‐induced pigmentation. Repented photopatch testing at the same skin site produced an increase in sensitivity. Eye colour, natural susceptibility to suntanning, age, and sex, had no effect on the phototoxic response to psoralens.