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Tobramycin‐neomycin cross‐sensitivity
Author(s) -
Schorr William F.,
Ridgway Hal B.
Publication year - 1977
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1977.tb03627.x
Subject(s) - tobramycin , neomycin , medicine , aminoglycoside , antibiotics , dermatology , pharmacology , chemistry , gentamicin , biochemistry
Fifty normal control volunteers were patch tested to 20% neomycin as well as tobramycin 1%, 10%, 20% and 30% in white petrolatum. Tobramycin is a new aminoglycoside antibiotic for prescription Ophthalmologic use in the United States. There were no reactions on any of the control volunteers. Twenty known and proven neomycin‐allergic patients were then tested to tobramycin 10 % and 20 % in white petrolatum, as well as to neomycin 20 % aqueous and 20 % in white petrolatum. All 20 reacted with a 2+ or greater response to the neomycin patch tests. Twelve out of the 20 or 60 % of the neomycin‐allergic patients reacted to the 10 % tobramycin in white petrolatum. Thirteen out of 20 or 65 % reacted to 20 % tobramycin in while petrolatum. From these data, tobramycin (ophthalmic) should not be used to treat known neomycin‐allergic patients without first patch tolling the patient with 20 % tobramycin in white petrolatum. It appears probable that 65 % of neomycin‐allergic patients would react with a dermatitic response to such therapy.