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Psoralen photoallergy caused by plant contact
Author(s) -
Ljunggren Bo
Publication year - 1977
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1977.tb03604.x
Subject(s) - patch test , dermatology , sensitization , contact dermatitis , imperatorin , contact allergy , psoralen , allergy , allergic contact dermatitis , benzocaine , phototoxicity , serial dilution , medicine , chemistry , pathology , immunology , organic chemistry , dna , biochemistry , high performance liquid chromatography , alternative medicine , in vitro
A case of acquired photocontact allergy to furocumarins in plants is reported. Photopatch testing was performed with four psoralens [8‐melhoxypsoralen (8‐MOP), 5‐methoxypsoralens (5‐MOP), trimethylpsoralen (TMP) and imperatorin (IMP)]. The use of serial dilutions of the test compounds made it possible to differentiate between photoallergic and phototoxic reactions. 8‐MOP gave a positive eczematous text reaction down to a concentration of 0.0001% The reactions to 5‐MOP and IMP also were positive, while that to TMP was negative. Histopathological examination of a biopsy specimen from a positive test site showed changes consistent with photoallergic contact dermatitis. The multiple reactions could be explained on the basis of multiple sensitization, but cross reactions cannot be ruled out.