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The chamber‐scarification test for irritancy *
Author(s) -
Frosch Peter J.,
Kligman Albert M.
Publication year - 1976
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1976.tb03068.x
Subject(s) - scarification , reproducibility , patch test , forearm , contact dermatitis , medicine , surgery , biomedical engineering , dermatology , chemistry , chromatography , allergy , biology , botany , germination , dormancy , immunology
A procedure has been designed (the chamber‐scarification test), which possesses greatly increased sensitivity for assessing the irritancy of topically applied materials. A forearm test site is criss‐cross scarified by drawing a 30‐gauge needle over the skin with just enough pressure to cleave the epidermis without drawing blood. The test agent is applied in an aluminum chamber once daily for 3 days. The advantages of the method over conventional patch testing are: enhanced capacity to measure mild irritants, reduced time (3 days versus 10 to 21 days), less effort, less cost, less discombort for the volunteers and greater reproducibility.