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Histological differences between irritant and allergic patch test reactions in man *
Author(s) -
Nater J. P.,
Hoedemaeker Ph. J.
Publication year - 1976
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1976.tb03042.x
Subject(s) - patch test , skin reaction , patch testing , dermatology , allergic reaction , irritant contact dermatitis , allergic contact dermatitis , allergy , skin test , medicine , contact dermatitis , pathology , immunology , tuberculosis
The results of a study of the histological aspects of the application of DNCB on the skin of unsensitized and sensitized persons are discussed. The nature of the histological changes in primary irritant and allergic reactions to DNCB in human skin appeared to be identical. The differences appeared to be primarily of a quantitative character. It is furthermore concluded from data in the literature that the skin of some persons may read with a primary irritant reaction to concentrations of a compound thought to cause only allergic reactions. In these persons histological examination of the patch test result may give insufficient clues us to the nature of the reaction. The practical consequences of the data presented arc discussed.