Premium
Squaric‐acid‐diethylester ‐ a strong sensitizer
Author(s) -
Noster U.,
Hausen B. M.,
Krische B.,
Schulz K. H.
Publication year - 1976
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1976.tb02993.x
Subject(s) - squaric acid , sensitization , chemistry , guinea pig , allergic contact dermatitis , biochemistry , medicine , organic chemistry , immunology , allergy
A patient developed a circumscribed contact dermatitis after a single contact with squaric‐acid‐diethylester (SADE). Patch tests with low concentrations of SADE were positive. Based on these observations, experimental studies on the sensitizing capacity of SADE were performed on guinea‐pigs. The results disclosed that this compound is a strong sensitizer. Derivatives of SADE, such as the nearly insoluble squaric acid, squaric‐acid‐1, 2‐diarnide and dithio‐N, N′‐dicyclohexyte‐1,2‐diamide were not able to produce allergic skin reactions in the sensitized patient nor in guinea‐pigs. The chemistry and the range of uses of squaric acid and its derivatives are briefly mentioned. A hypothesis on the molecular mechanism of conjugation of SADE to human proteins and thereby on sensitization is discussed. A warning is given for taking precautionary measures before handling this substance.