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Effect of some irritants on human epidermal mitosis
Author(s) -
Fisher Louis B.,
Maibach Howard I.
Publication year - 1975
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1975.tb05434.x
Subject(s) - benzalkonium chloride , chemistry , mitosis , contact dermatitis , irritation , psoriasis , hydrochloric acid , immunology , pharmacology , biochemistry , microbiology and biotechnology , medicine , biology , allergy , chromatography , organic chemistry
Studies on how irritant materials might induce epidermal hyperplasia were initiated by investigating their influence on epidermal mitosis. 5 % hydrochloric acid, neat dimethyl acetamide and 1 % benzalkonium chloride had no effect. 5 % benzalkonium chloride, however, produced a 10‐fold increase in mitotic activity, while a dose response curve was seen with sodium lauryl sulphate (SLS) peaking at 1 %, 1 % SLS produced a remarkably uniform response for this type of assay and it is suggested that it might provide a useful model for situations of increased epidermal cell turnover such as psoriasis. It is also noted that there was apparently no direct relationship between gross inflammation and the mitotic response.