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Value of a new technique of sensitization to dinitro‐2, 4‐chlorobenzene
Author(s) -
Foussereau J.,
Herrmann B.,
Grosshans E.,
Petitjean J.,
Maleville J.
Publication year - 1975
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1975.tb05382.x
Subject(s) - sensitization , chlorobenzene , skin sensitization , medicine , immunology , dermatology , toxicology , chemistry , organic chemistry , catalysis , biology
Experimental sensitization to dtnitro‐2,4‐chlorohenzene (DNCB) is being studied according to different techniques, the variable factors being the concentrations of DNCB, the number of applications and the time between the sensitizing application and the reading of the challenge test. The authors relate and discuss their technique (only one touch of a drop of 10% DNCB in acetone, covered with a cover‐slip and left to evaporate), the results and the advantages; in particular, standardization of the parameters of sensitization, (quantity of DNCB, area and time of application) and reduction in the risk of toxic effects inherent in excessively high concentrations of DNCB. In addition, the authors emphasize the fundamental significance of the length of time needed to acquire experimental sensitization.