Premium
Non‐surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial
Author(s) -
H. Bokhari Syed A.,
Khan Ayyaz A.,
Butt Arshad K.,
Azhar Mohammad,
Hanif Mohammad,
Izhar Mateen,
Tatakis Dimitris N.
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01942.x
Subject(s) - medicine , fibrinogen , periodontitis , randomized controlled trial , c reactive protein , chronic periodontitis , oral hygiene , scaling and root planing , gastroenterology , dentistry , inflammation
Aim Periodontal disease elevates systemic inflammatory markers strongly associated with coronary heart disease (CHD) risk. The aim of this randomized controlled trial was to investigate the effect of non‐surgical periodontal therapy on systemic C‐reactive protein ( CRP ), fibrinogen and white blood cells in CHD patients. Materials and Methods Angiographically proven CHD patients with periodontitis ( n = 317) were randomized to intervention ( n = 212) or control group ( n = 105). Primary outcome was reduction in serum CRP levels; secondary outcomes were reductions in fibrinogen and white blood cells. Periodontal treatment included scaling, root planing and oral hygiene instructions. Periodontal and systemic parameters were assessed at baseline and at 2‐month follow‐up. Intent‐to‐treat ( ITT ) analysis was performed. Results Study was completed by 246 subjects (intervention group = 161; control group = 85). Significant improvements in periodontal and systemic parameters were observed in intervention group. The number of subjects with CRP > 3mg/L in intervention group decreased by 38% and in control group increased by 4%. ITT analysis gave a significant ( χ 2 =4.381, p = 0.036) absolute risk reduction of 12.5%. Conclusion In CHD patients with periodontitis, non‐surgical mechanical periodontal therapy significantly reduced systemic levels of C‐reactive protein, fibrinogen and white blood cells.