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Whole mouth antimicrobial effects after oral hygiene: comparison of three dentifrice formulations
Author(s) -
Fine Daniel H.,
Sreenivasan Prem K.,
McKiernan Marie,
TischioBereski Debra,
Furgang David
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01938.x
Subject(s) - dentifrice , veillonella , sodium hexametaphosphate , triclosan , saliva , sodium fluoride , dentistry , antimicrobial , fusobacteria , dental plaque , medicine , fluoride , food science , chemistry , microbiology and biotechnology , sodium , bacteria , streptococcus , biology , biochemistry , inorganic chemistry , bacteroidetes , genetics , 16s ribosomal rna , organic chemistry , pathology , gene
Aims This study compared the antimicrobial effects of three commercial dentifrice formulations: sodium fluoride/triclosan/copolymer ( TCN /C), stannous fluoride/sodium hexametaphosphate/zinc lactate (SnF 2 / SHMP ) and sodium fluoride (NaF). Materials and Methods Thirty‐five adults (15 men and 20 women; average age 33 years and pockets <5 mm) completed this double‐blind, triple‐crossover study. After washout, baseline samples from four sites, plaque, saliva, tongue and buccal mucosa, were collected and evaluated for six microbial types, anaerobes, Streptococci , Actinomyces , hydrogen‐sulphide (H 2 S)‐producing bacteria, Fusobacteria and Veillonella . A specific dentifrice was randomly assigned for twice‐daily use for 13 days. On day 14, 12 h after brushing, samples were collected for microbiological evaluations. Alternate dentifrices followed this identical protocol. Results For all four oral sites and six organisms evaluated in each site, the TCN /C demonstrated significant reductions (49–83%) as compared with the other treatments ( p < 0.01). The SnF 2 / SHMP group showed significant reductions of 14–43% for 14 of 24 outcomes as compared with the NaF group ( p < 0.01), with no differences in 10 outcomes. Conclusions The TCN /C dentifrice formulation consistently demonstrated significant reductions for a range of microorganisms in diverse oral sites in comparison with the NaF, or the SnF 2 / SHMP dentifrice formulations as seen 12 h after brushing.