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The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1‐year double‐blinded, placebo‐controlled, randomized clinical trial
Author(s) -
Mestnik Maria J.,
Feres Magda,
Figueiredo Luciene C.,
Soares Geisla,
Teles Ricardo P.,
Fermiano Daiane,
Duarte Poliana M.,
Faveri Marcelo
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01932.x
Subject(s) - medicine , amoxicillin , metronidazole , scaling and root planing , aggressive periodontitis , placebo , adjunctive treatment , gastroenterology , randomized controlled trial , periodontitis , clinical trial , antibiotics , chronic periodontitis , pathology , alternative medicine , microbiology and biotechnology , biology
Aim To evaluate the clinical effects of the adjunctive use of metronidazole ( MTZ ) and amoxicillin ( AMX ) in the treatment of generalized aggressive periodontitis ( GAgP ). Methods Thirty subjects were randomly assigned to receive scaling and root planing ( SRP ) alone or combined with MTZ (400 mg/TID) and AMX (500 mg/TID) for 14 days. Subjects were clinically monitored at baseline, 6 months and 1 year post‐therapies. Results Both therapies led to a statistically significant improvement in all clinical parameters at 1 year post‐therapy ( p < 0.05). Subjects receiving MTZ plus AMX exhibited the deepest reductions in mean probing depth ( PD ) and gain in clinical attachment between baseline and 1 year post‐therapy in the full‐mouth analysis and in initially intermediate ( PD 4–6 mm) and deep ( PD ≥7 mm) sites ( p < 0.01). In addition, the antibiotic group presented lower mean number of residual sites with PD ≥5 or 6 mm as well as fewer subjects still presenting nine or more sites with PD ≥5 mm or three or more sites with PD ≥6 mm at the end of the study period. Conclusion The non‐surgical treatment of GAgP is markedly improved by the adjunctive use of MTZ + AMX , up to 1 year post‐treatment.