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Vitamin C in plasma and leucocytes in relation to periodontitis
Author(s) -
Kuzmanova Denica,
Jansen Ineke D. C.,
Schoenmaker Ton,
Nazmi Kamran,
Teeuw Wijnand J.,
Bizzarro Sergio,
Loos Bruno G.,
Velden Ubele
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01927.x
Subject(s) - periodontitis , medicine , vitamin , peripheral blood mononuclear cell , endocrinology , vitamin c , vitamin e , vitamin d and neurology , immunology , chemistry , biochemistry , antioxidant , in vitro
Aim To test the hypothesis that vitamin C concentrations in plasma, polymorphonuclear neutrophilic leucocytes ( PMN s) and peripheral blood mononuclear cells ( PBMC s) are lower in periodontitis patients compared with healthy controls. Methods Twenty‐one untreated periodontal patients and 21 healthy controls matched for age, gender, race and smoking habits were selected. Dietary vitamin C intake was assessed by a self‐administered dietary record. Fasting blood samples were obtained and analysed for vitamin C concentrations in plasma, PMN s and PBMC s by means of high‐pressure liquid chromatography ( HPLC ). Results Plasma vitamin C was lower in periodontitis patients compared with controls (8.3 and 11.3 mg/l, respectively, p = 0.03). Only in the control group a positive correlation was present between vitamin C intake and plasma values. No differences could be assessed between patients and controls regarding vitamin C dietary intake and levels in PMN s and PBMC s. In the patient group, pocket depth appeared to be negatively associated with the vitamin C concentration in PMN s. Conclusion Although the relationship between low plasma vitamin C levels and periodontitis is clear, the disease cannot be explained by insufficient vitamin C storage capacity of leucocytes; the question remains through which mechanism low plasma vitamin C levels are related to periodontitis.