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All‐cause mortality and periodontitis in 60–70‐year‐old men: a prospective cohort study
Author(s) -
Linden Gerard J.,
Linden Katie,
Yarnell John,
Evans Alun,
Kee Frank,
Patterson Chris C.
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01923.x
Subject(s) - medicine , prospective cohort study , hazard ratio , periodontitis , proportional hazards model , confounding , clinical attachment loss , cohort study , cohort , population , diabetes mellitus , tooth loss , demography , dentistry , confidence interval , endocrinology , oral health , environmental health , sociology
Objective To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60‐ to 70‐year‐old West E uropean men. Methodology A representative sample of 1400 dentate men, (mean age 63.8, SD 3.0 years), drawn from the population of N orthern I reland, had a comprehensive periodontal examination between 2001 and 2003. Men were divided into thirds on the basis of their mean periodontal attachment loss ( PAL ). The primary endpoint, death from any cause, was analysed using K aplan– M eier survival plots and C ox's proportional hazards model. Results In total, 152 (10.9%) of the men died during a mean follow‐up of 8.9 ( SD 0.7) years; 37 (7.9%) men in the third with the lowest PAL (<1.8 mm) died compared with 73 (15.7%) in the third with the highest PAL (>2.6 mm). The unadjusted hazard ratio ( HR ) for death in the men with the highest level of PAL compared with those with the lowest PAL was 2.11 (95% CI 1.42–3.14), p < 0.0001. After adjustment for confounding variables (age, smoking, hypertension, BMI , diabetes, cholesterol, education, marital status and previous history of a cardiovascular event) the HR was 1.57 (1.04–2.36), p = 0.03. Conclusion The European men in this prospective cohort study with the most severe loss of periodontal attachment were at an increased risk of death compared with those with the lowest loss of periodontal attachment.