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Serum lipids modify periodontal infection ‐ C ‐reactive protein association
Author(s) -
Haro Anniina,
Saxlin Tuomas,
Suominen AnnaLiisa,
Ylöstalo Pekka,
Leiviskä Jaana,
Tervonen Tellervo,
Knuuttila Matti
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01920.x
Subject(s) - c reactive protein , inflammation , medicine , systemic inflammation , cholesterol , gingival and periodontal pocket , diabetes mellitus , clinical attachment loss , immunology , periodontitis , gastroenterology , dentistry , endocrinology
Aim To investigate whether low‐grade inflammation‐related factors such as serum low‐density ( LDL ‐C) and high‐density lipoprotein cholesterol ( HDL ‐C) modify the association between periodontal infection and C‐reactive protein. Material and Methods This study was based on a subpopulation of the Health 2000 Survey, which consisted of dentate, non‐diabetic, non‐rheumatic subjects who were 30–49 years old ( n = 2710). The extent of periodontal infection was measured by means of the number of teeth with periodontal pocket ≥4 mm and teeth with periodontal pocket ≥6 mm and systemic inflammation using high sensitive C‐reactive protein. Results The extent of periodontal infection was associated with elevated levels of C‐reactive protein among those subjects whose HDL ‐C value was below the median value of 1.3 mmol/l or LDL ‐C above the median value of 3.4 mmol/l. Among those with HDL ‐C ≥ 1.3 mmol/l or LDL ‐C ≤ 3.4 mmol/l, the association between periodontal infection and serum concentrations of C‐reactive protein was practically non‐existent. Conclusion This study suggests that the relation of periodontal infection to the systemic inflammatory condition is more complicated than previously presumed. The findings of this study suggest that the possible systemic effect of periodontal infection is dependent on serum lipid composition.