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Systemic antibiotics and debridement of peri‐implant mucositis. A randomized clinical trial
Author(s) -
Hallström Hadar,
Persson G. Rutger,
Lindgren Susann,
Olofsson Maria,
Renvert Stefan
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01884.x
Subject(s) - mucositis , medicine , antibiotics , systemic antibiotics , implant , debridement (dental) , peri implantitis , randomized controlled trial , dentistry , surgery , bleeding on probing , clinical trial , periodontitis , chemotherapy , microbiology and biotechnology , biology
Background This RCT compared non‐surgical treatment of peri‐implant mucositis with or without systemic antibiotics. Materials and Methods Forty‐eight subjects received non‐surgical debridement with or without systemic Azithromax ® (4 days), and were followed during 6 months. The checkerboard DNA ‐ DNA hybridization method was used to analyse the microbiological material. Results Five subjects were excluded due to antibiotic medication during follow‐up. At baseline,1 and 3 months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths ( PPD ) values at 6 months (Mean diff PPD : 0.5 mm, SE : ±0.4 mm, 95% CI : −0.2, 1.3, p = 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group ( p < 0.02). Throughout the study, no study group differences in bacterial counts were found. Conclusion No short‐term differences were found between study groups. The clinical improvements observed at 6 months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri‐implant mucositis.