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Regenerative therapy of infrabony defects with or without systemic doxycycline. A randomized placebo‐controlled trial
Author(s) -
Röllke Lasse,
Schacher Beate,
Wohlfeil Martin,
Kim TiSun,
Kaltschmitt Jens,
Krieger Jörg,
Krigar Diana M.,
Reitmeir Peter,
Eickholz Peter
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2012.01861.x
Subject(s) - doxycycline , enamel matrix derivative , medicine , placebo , random assignment , surgery , randomized controlled trial , systemic administration , dentistry , pathology , alternative medicine , microbiology and biotechnology , regeneration (biology) , in vivo , biology , antibiotics
Aim Comparison of regenerative therapy of infrabony defects with and without administration of postsurgical systemic doxycycline ( DOXY ). Methods In each of 61 patients one infrabony defect was treated with enamel matrix derivative ( EMD ), EMD plus filler or membrane at two centres. By random assignment patients received either 200 mg DOXY per day or placebo ( PLAC ) for 7 days after surgery. Prior to and 6 months after surgery probing pocket depths ( PPD ) and vertical attachment level ( PAL ‐ V ) were obtained. Results Fifty‐four patients ( DOXY : 27; PLAC : 27) were re‐examined after 6 months and had been treated exclusively with EMD . Seven to 8 days after surgery 81% of defects in both groups showed complete flap closure. In both groups significant ( p < 0.001) PPD reduction ( DOXY : 3.87 ± 1.44 mm; PLAC : 3.67 ± 1.30 mm) and PAL ‐ V gain ( DOXY : 3.11 ± 1.50 mm; PLAC : 3.32 ± 1.83 mm) were observed. However, the differences failed to be statistically significant ( PPD : 0.20; p = 0.588; PAL ‐ V : 0.21; p = 0.657). Conclusions Two hundred milligram systemic DOXY administered for 7 days after therapy of infrabony defects with EMD failed to result in better PPD reduction and PAL ‐ V gain compared with PLAC which may be due to low power (50%) and, thus, random chance.