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Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans
Author(s) -
Thoma Daniel S.,
SanchoPuchades Manuel,
Ettlin Dominik A.,
Hämmerle Christoph H. F.,
Jung Ronald E.
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01823.x
Subject(s) - wound healing , medicine , surgery , dentistry , statistical significance
Aim To test whether a collagen matrix ( CM ) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. Methods In 15 volunteers, 6‐mm punch biopsies were harvested at both palatal sites. A CM was sutured in one site; the other one was left untreated (control). Measurements included the remaining defect area, the colour match to surrounding tissue and somatosensory parameters at various time‐points (pre‐operative, post‐operative, 4, 8, 15, 29 days). Results The defect area decreased over time for both treatments. Re‐epithelization was completed in all subjects by day 15. The defect area was significantly smaller for CM (mean ± SD: 19.3 ± 3.4 mm 2 ) compared with control (21.3 ± 3.3 mm 2 ) at day 4 ( p < 0.05), and at day 8 ( CM : 11.7 ± 2.5 mm 2 ; control: 13.6 ± 2.9 mm 2 ; p < 0.01). The colour match was more favourable for CM at day 4, 8 and 29 ( p > 0.05). Somatosensory measurements revealed slightly lower wound sensitivity at day 4 for CM compared with control. Conclusions The use of CM can enhance wound healing compared with spontaneous healing during the first week. This was mainly documented by a faster re‐epithelization. Colour match and wound sensitivity measurements did not reach statistical significance between CM and control sites.