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The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats
Author(s) -
Lütfioğlu Müge,
Sakallioğlu Umur,
Sakallioğlu Elif Eser,
Bariş Sancar,
Gürgör Pınar
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01814.x
Subject(s) - periodontium , saline , periodontitis , medicine , group a , hyperparathyroidism , osteoclast , endocrinology , periodontal fiber , dentistry , group b , pathology , receptor
Background and Objective Nutrition may be a potential modifying factor in periodontal conditions. The present study investigated this phenomenon for dietary induced hyperparathyroidism ( dHPT ) by revealing the histopathological and histomorphometrical profiles of healthy and diseased periodontia in dHPT . Methods Dietary induced hyperparathyroidism was induced in 12 rats by dietary calcium/phosphorous imbalance and 12 rats were fed standard diet ( SD ). Periodontitis was induced on the right mandibular molar teeth (mmt) of these rats by injecting an endotoxin + saline solution whereas injecting pure saline to the left mmt. Thus, four study groups were created: dHPT + saline (group 1), dHPT + endotoxin (group 2), SD + endotoxin (group 3) and SD + saline (group 4). Histological sections were obtained from the second mmt and examined using light microscope. Results Group 1 demonstrated inflammatory and degenerative alterations in periodontium without pocket formation. Periodontitis was evident in groups 2 and 3. Group 2 revealed the highest amounts of gingival inflammatory cell and vessel counts (group 2 > group 3 > group 1 > group 4), attachment and bone losses (group 2 > group 3 > groups 1 > group 4) and osteoclast count (group 2 > group 3 > group 1 > group 4) ( p < 0.05). Conclusion These results propose that dHPT may impair the health status of periodontium and may worsen the pathobiology of periodontal diseases.