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Low‐dose rh BMP 2/7 heterodimer to reconstruct peri‐implant bone defects: a micro‐ CT evaluation
Author(s) -
Wang Jingxiao,
Zheng Yuanna,
Zhao Juan,
Liu Tie,
Gao Lixia,
Gu Zhiyuan,
Wu Gang
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01807.x
Subject(s) - calvaria , implant , bone morphogenetic protein 2 , bone morphogenetic protein , x ray microtomography , dentistry , bone formation , chemistry , medicine , nuclear medicine , endocrinology , surgery , in vitro , radiology , biochemistry , gene
Objectives To delineate the dynamic micro‐architectures of bone induced by low‐dose bone morphogenetic protein ( BMP )‐2/7 heterodimer in peri‐implant bone defects compared to BMP 2 and BMP 7 homodimer. Material and Methods Peri‐implant bone defects (8 mm in diameter, 4 mm in depth) were created surrounding SLA ‐treated titanium implants (3.1 mm in diameter, 10 mm in length) in minipig's calvaria. We administrated collagen sponges with adsorbed low‐dose (30 ng/mm 3 ) BMP 2/7 to treat the defects using BMP 2, BMP 7 or no BMP as controls.2, 3 and 6 weeks after implantation, we adopted micro‐computer tomography to evaluate the micro‐architectures of new bone using the following parameters: relative bone volume ( BV / TV ), trabecular number ( Tb.N ), trabecular thickness ( Tb.Th ), trabecular separation ( Tb.Sp ), connectivity density, and structure mode index ( SMI ). Bone implant contact ( BIC ) was also revealed histologically. Results Consistent with 2 and 3 weeks, after 6 weeks post‐operation, BMP 2/7 resulted in significantly higher BV / TV (63.033 ± 2.055%) and significantly lower SMI (−4.405 ± 0.500) than BMP 2 ( BV / TV : 43.133 ± 2.001%; SMI : −0.086 ± 0.041) and BMP 7 ( BV / TV : 41.467 ± 1.850%; SMI : −0.044 ± 0.016) respectively. Significant differences were also found in Tb.N, Tb.Th and Tb.Sp at all time points. At 2 weeks, BMP 2/7 resulted in significantly higher BIC than the controls. Conclusions Low‐dose BMP 2/7 heterodimer facilitated more rapid bone regeneration in better quality in peri‐implant bone defects than BMP 2 and BMP 7 homodimers.