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Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double‐blind RCT
Author(s) -
Chapple Iain L. C.,
Milward Michael R.,
LingMountford Nicola,
Weston Paul,
Carter Kevin,
Askey Keeley,
Dallal Gerard E.,
De Spirt Silke,
Sies Helmut,
Patel Dina,
Matthews John B.
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01793.x
Subject(s) - medicine , placebo , micronutrient , bleeding on probing , periodontitis , randomized controlled trial , bioavailability , clinical trial , nutritional supplementation , berry , chronic periodontitis , dentistry , pharmacology , biology , botany , alternative medicine , pathology
Aim A double‐blind randomized controlled trial to determine whether dietary supplementation with fruit/vegetable/berry juice powder concentrates, simultaneously with non‐surgical periodontal therapy, improved 2‐month treatment outcomes. Methods Volunteers with chronic periodontitis were randomly assigned to one of three groups: fruit/vegetable (FV), fruit/vegetable/berry (FVB) or placebo. Supplements were taken daily during non‐surgical debridement and maintenance and outcomes assessed at 2, 5 and 8 months after completion. Primary outcomes were mean probing pocket depth (PPD), clinical attachment gain, % sites bleeding on probing (% BOP) at 2 months. Adherence and plasma β‐carotene were determined. Results Sixty‐one nutritionally replete (by serum biochemistry) volunteers enrolled and 60 ( n = 20 per arm) completed the 2‐month review. Clinical outcomes improved in all groups at 2 months, with additional improvement in PPD versus placebo for FV ( p < 0.03). Gingival crevicular fluid volumes diminished more in supplement groups than placebo (FVB; p < 0.05) at 2 months, but not at later times. The % BOP (5 months) and cumulative plaque scores (8 months) were lowered more in the FV group ( p < 0.05). Conclusions Adjunctive juice powder concentrates appear to improve initial pocket depth reductions in nutritionally replete patients, where plasma micronutrient bioavailability is attainable. Definitive multicentre studies in untreated and treated patients are required to ascertain the clinical significance of such changes.