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Serum high‐density lipoprotein cholesterol level associated with the extent of periodontal inflammation in type 1 diabetic subjects
Author(s) -
Passoja Anna,
Knuuttila Matti,
Hiltunen Liisa,
Karttunen Riitta,
Niemelä Onni,
Raunio Taina,
Vainio Olli,
Hedberg Pirjo,
Tervonen Tellervo
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01792.x
Subject(s) - medicine , inflammation , high density lipoprotein , cholesterol , endocrinology , c reactive protein , lipoprotein , gastroenterology
Aim High‐density lipoprotein ( HDL ) cholesterol is known for its anti‐inflammatory and antioxidant activities in protection against cardiovascular diseases. We investigated whether a protective association also exists between serum HDL and periodontal inflammation in type 1 diabetic subjects ( T1DM ). Methods Plaque and periodontal inflammation (bleeding and PD ≥ 4 mm) were examined in 80 subjects with T1DM . The serum levels of glycosylated haemoglobin ( HbA1c , %) and HDL (mmol/l) were determined. Adjusted associations between inflammation and serum HDL were analysed using linear regression analysis. To study the linearity of the association, the subjects were categorized into HDL tertiles ( I‐III ). Results A statistically significant negative association was observed between serum HDL level and the extent of bleeding and PD ≥ 4 mm. Subjects in HDL tertiles II and III (high HDL ) presented significantly fewer inflamed sites when compared with the subjects in tertile I (low HDL ), whereas no significant difference in the number of inflamed sites was observed between tertiles II and III . Conclusions Based on the finding of a negative association between serum HDL and periodontal inflammation, HDL may be considered a marker of susceptibility to periodontal inflammation. A longitudinal study is needed to verify possible causal relationship between serum HDL and inflammation.