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Clinical and histological healing of a new collagen matrix in combination with the coronally advanced flap for the treatment of Miller class‐I recession defects: an experimental study in the minipig
Author(s) -
Vignoletti Fabio,
Nuñez Javier,
Discepoli Nicola,
De Sanctis Francesco,
Caffesse Raul,
Muñoz Fernando,
Lopez Monica,
Sanz Mariano
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01767.x
Subject(s) - cementum , medicine , connective tissue , regeneration (biology) , dentistry , gingival recession , junctional epithelium , matrix (chemical analysis) , pathology , biology , chemistry , dentin , microbiology and biotechnology , chromatography
Vignoletti F, Nuñez J, Discepoli N, De Sanctis F, Caffesse R, Muñoz F, Lopez M, Sanz M: Clinical and histological healing of a new collagen matrix in combination with the coronally advanced flap for the treatment of Miller class‐I recession defects: an experimental study in the minipig. J Clin Periodontol 2011; 38: 847–855. doi: 10.1111/j.1600‐051X.2011.01767.x. Abstract Aim: To describe the histological and clinical outcomes of the use of a xenogeneic collagen matrix (CM) in combination with the coronally advanced flap (CAF) in the treatment of localized Miller class‐I gingival recessions. Material and Methods: Gingival recession defects were surgically created on 12 minipigs. The defects were randomly treated with either the CAF procedure and the interposition of a CM (test) or the CAF alone (control). Clinical and histological outcomes at 1, 4 and 12 weeks were evaluated. Results: Histometrically, in the test group, there was a shorter junctional epithelial dimension [2.26 (SD 0.23) mm] compared with the control [2.79 (SD 0.77) mm]. On the contrary, the amount of newly formed cementum was larger in the test group [1.08 (SD 0.41) mm] than in the control group [0.75 (SD 0.25) mm], although the differences were not statistically significant. Conclusions: Both techniques rendered similar clinical outcomes, achieving complete root coverage at the end of the study. Nevertheless, the CM graft attained more tissue regeneration, characterized by a shorter epithelium and a larger new cementum formation. The use of a xenogeneic CM resulted in the incorporation of the xenograft within the adjacent host connective tissues in the absence of significant inflammation.