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Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: a randomized placebo‐controlled clinical trial
Author(s) -
Sampaio Eduardo,
Rocha Marcelo,
Figueiredo Luciene Cristina,
Faveri Marcelo,
Duarte Poliana Mendes,
Gomes Lira Eisla Alline,
Feres Magda
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01766.x
Subject(s) - scaling and root planing , azithromycin , medicine , chronic periodontitis , periodontitis , placebo , randomized controlled trial , clinical trial , dentistry , gastroenterology , antibiotics , biology , pathology , microbiology and biotechnology , alternative medicine
Sampaio E, Rocha M, Figueiredo LC, Faveri M, Duarte PM, Lira EAG, Feres M: Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: a randomized placebo‐controlled clinical trial. J Clin Periodontol 2011; 38: 838–846. doi: 10.1111/j.1600‐051X.2011.01766.x. Abstract Aim: To evaluate the effects of systemic azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of generalized chronic periodontitis (ChP). Methods: Forty subjects were randomly assigned to receive SRP alone or combined with AZM (500 mg/day) for 5 days ( n =20/group). Clinical and microbiological examinations were performed at baseline, 6 months and 1‐year post‐SRP. Nine plaque samples per subject were analysed by checkerboard DNA–DNA hybridization for 40 bacterial species. Differences between groups were assessed using the Mann–Whitney test and over time using Friedman and Dunn's tests. Results: No statistically significant differences were observed between groups for any parameters evaluated at 1‐year post‐treatments. Both therapies equally reduced the mean probing depth (PD) (SRP: 3.83 ± 1.92, AZM: 3.45 ± 1.74) and improved the mean clinical attachment (SRP: 2.35 ± 1.70, AZM: 2.68 ± 1.76) in sites with initial PD7 mm (primary outcome variable) between baseline and 1 year. The mean counts and proportions of several periodontal pathogens were reduced, and those of host‐beneficial species were increased after treatments. Nonetheless, an important recolonization with red complex species was observed in both groups over the course of the study. Conclusion: The data of the present study suggest no adjunctive benefit of AZM in the treatment of generalized ChP.