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Endotoxemia and the host systemic response during experimental gingivitis
Author(s) -
Wahaidi Vivian Y.,
Kowolik Michael J.,
Eckert George J.,
Galli Dominique M.
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01710.x
Subject(s) - gingivitis , fibrinogen , medicine , interleukin 6 , c reactive protein , acute phase protein , immunology , inflammation , dentistry
Wahaidi VY, Kowolik MJ, Eckert GJ, Galli DM: Endotoxemia and the host systemic response during experimental gingivitis. J Clin Periodontol 2011; 38: 412–417. doi: 10.1111/j.1600‐051X.2011.01710.x. Abstract Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)‐1 β , IL‐6, IL‐8, C‐reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline ( p <0.05). In the endotoxin‐negative group this increase was associated with the black subjects whereas in the endotoxin‐positive group change in neutrophil activity was driven by the female subpopulation. Serum cytokines, CRP, and fibrinogen levels did not change during the study. Conclusions: Experimental gingivitis was associated with endotoxemia and hyperactivity of circulating neutrophils, but not with changes in systemic levels of cytokines and acute‐phase proteins. This may be attributed to the mild nature and the short duration of the induced gingivitis.