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Salivary biomarkers of periodontal disease in response to treatment
Author(s) -
Sexton William M.,
Lin Yushun,
Kryscio Richard J.,
Dawson Dolphus R.,
Ebersole Jeffrey L.,
Miller Craig S.
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2011.01706.x
Subject(s) - medicine , osteoprotegerin , saliva , periodontitis , scaling and root planing , gastroenterology , chronic periodontitis , periodontal disease , oral hygiene , matrix metalloproteinase , dentistry , receptor , activator (genetics)
Sexton WM, Lin Y, Kryscio RJ, Dawson III DR, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol 2011; 38: 434–441. doi: 10.1111/j.1600‐051X.2011.01706.x Abstract Background: Salivary biomarkers of periodontitis were assessed longitudinally to determine response to therapy. Methods: A 6‐month case‐controlled study of adults with chronic periodontitis was performed, with 33 participants receiving oral hygiene instructions (OHI) alone and 35 with scaling and root planing (SRP) combined with OHI. Saliva samples collected at week 0, 16 and 28 were analysed for interleukin (IL)‐1 β , IL‐8, macrophage inflammatory protein (MIP)‐1 α , matrix metalloproteinase‐8 (MMP‐8), osteoprotegerin (OPG), and tumour necrosis factor‐ α (TNF)‐ α . Clinical measures of periodontal disease were recorded at each visit. Results: All parameters of periodontal health improved significantly in both groups by week 16 ( p <0.0001) with the SRP group demonstrating greater benefit at week 16 and 28. Baseline OPG and TNF‐ α levels changed significantly at both follow‐up visits ( p <0.03), regardless of treatment group. IL‐1 β and MMP‐8 levels decreased significantly from baseline ( p <0.04) in the SRP group only. OPG, MMP‐8, and MIP‐1 α were significantly reduced in responders compared with non‐responders ( p =0.04, 0.01, 0.05, respectively). In receiver‐operating characteristic analyses, MMP‐8 produced the highest area under the curve (0.7; p =0.01). Conclusion: Salivary levels of IL‐1 β , MMP‐8, OPG, and MIP‐1 α reflected disease severity and response to therapy suggesting their potential utility for monitoring periodontal disease status.