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Bsm I, Taq I, Apa I, and Fok I polymorphisms in the vitamin D receptor gene and periodontitis: a meta‐analysis of 15 studies including 1338 cases and 1302 controls
Author(s) -
Deng Hui,
Liu Fen,
Pan YiHuai,
Jin XiangQing,
Wang HuiNing,
Cao JinFang
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01685.x
Subject(s) - taqi , foki , calcitriol receptor , chronic periodontitis , medicine , meta analysis , genotype , odds ratio , gastroenterology , vitamin d and neurology , periodontitis , genetics , polymorphism (computer science) , biology , gene
Deng H, Liu F, Pan Y, Jin X, Wang H, Cao J. Bsm I, Taq I, Apa I and Fok I polymorphisms in the vitamin D receptor gene and periodontitis: a meta‐analysis of 15 studies including 1338 cases and 1302 controls. J Clin Periodontol 2011; 38: 199–207. 38: 199–207. doi: 10.1111/j.1600‐051X.2010.01685.x Abstract Aim: A meta‐analysis was conducted in order to investigate the potential association of vitamin D receptor (VDR) gene polymorphisms with susceptibility to aggressive and chronic periodontal disease. Material and Methods: A database search yielded a total of 15 studies involving 1338 cases and 1302 controls. Four polymorphisms were included in the meta‐analysis: VDR Taq I (rs731236), VDR Bsm I (rs1544410), VDR Fok I (rs2228570), and VDR Apa I (rs7975232). Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The combined results based on all studies showed that (1) chronic periodontitis cases had a significantly lower frequency of bb genotype of Bsm I [OR=0.63, 95% CI=0.42, 0.94; p =0.02] in Asians; (2) chronic periodontitis cases had a significantly higher frequency of AA genotype of Apa I (OR=2.20, 95% CI=1.39, 3.48; p <0.001) in Asians; (3) chronic periodontitis cases had a weak significantly higher frequency of TT genotype of Taq I (OR=1.86, 95% CI=1.002, 3.46; p =0.049) in Asians. After Bonferroni's correction, we found that in Asians chronic periodontitis cases still had a significantly higher frequency of AA genotype of Apa I. No significant difference was found in any genotype of Fok I. No association was found for all the VDR gene polymorphisms examined as far as the aggressive form of the disease is concerned. Future studies need to focus on the possible biological consequences and mechanisms of the VDR genetic variants. The current findings confirm that VDR gene is a candidate gene for periodontitis.