Premium
What can the periodontal community learn from the pathophysiology of rheumatoid arthritis?
Author(s) -
Culshaw Shauna,
McInnes Iain B.,
Liew Foo Y.
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01669.x
Subject(s) - medicine , rheumatoid arthritis , ankylosing spondylitis , periodontitis , psoriatic arthritis , pathogenesis , disease , narrative review , immunology , arthritis , inflammation , intensive care medicine , pathology
Culshaw S, McInnes IB, Liew FY: What can the periodontal community learn from the pathophysiology of rheumatoid arthritis? J Clin Periodontol 2011; 38 (Suppl. 11): 106–113. doi: 10.1111/j.1600‐051X.2010.01669.xAbstract Aim: The aim of this paper is to provide a narrative review of the aetiopathogeneis and treatments of rheumatoid arthritis (RA), focusing on aspects that may share commonality with periodontitis. Results: A myriad of cell types, cytokines and pathways have been investigated in both periodontitis and RA. Chronic inflammatory diseases, including RA, psoriatic arthritis, ankylosing spondylitis and periodontitis are likely to share pathogenic mechanisms of inflammation‐mediated solid tissue destruction. The aetiopathogenesis of these diseases has been extensively researched over the last several decades and advances in understanding have revolutionized arthritis therapeutics. Conclusion: The rational, targeted inhibition of mediators in RA has provided clinically useful therapeutics and shed light on mechanisms underpinning disease pathogenesis. RA should be considered a prototypic disease revealing how understanding disease pathogenesis may transform therapeutic options and patient outcomes.