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Functional interferences in host inflammatory immune response by airway allergic inflammation restrain experimental periodontitis development in mice
Author(s) -
da Fonseca Denise Morais,
Trombone Ana Paula Fávaro,
Repeke Carlos Eduardo,
AvilaCampos Mario Julio,
CoelhoCastelo Arlete A. M.,
Silva João Santana,
Campanelli Ana Paula,
Deperon Bonato Vânia Luiza,
Garlet Gustavo Pompermaier
Publication year - 2011
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01660.x
Subject(s) - immunology , inflammation , ovalbumin , immune system , periodontitis , medicine , sensitization , cytokine , tumor necrosis factor alpha , foxp3
da Fonseca DM, Trombone APF, Repeke CE, Avila‐Campos MJ, Coelho‐Castelo AAM, Silva JS, Campanelli AP, Bonato VLD, Garlet GP. Functional interferences in host inflammatory immune response by airway allergic inflammation restrain experimental periodontitis development in mice. J Clin Periodontol 2011; 38: 131–141. doi: 10.1111/j.1600‐051X.2010.01660.x Abstract Aims: Periodontal disease (PD) and airway allergic inflammation (AL) present opposing inflammatory immunological features and clinically present an inverse correlation. However, the putative mechanisms underlying such opposite association are unknown. Material and Methods: Balb/C mice were submitted to the co‐induction of experimental PD (induced by Actinobacillus actinomycetemcomitans oral inoculation) and AL [induced by sensitization with ovalbumin (OVA) and the subsequent OVA challenges], and evaluated regarding PD and AL severity, immune response [cytokine production at periodontal tissues, and T‐helper transcription factors in submandibular lymph nodes (LNs)] and infection parameters. Results: PD/AL co‐induction decreased PD alveolar bone loss and periodontal inflammation while experimental AL parameters were unaltered. An active functional interference was verified, because independent OVA sensitization and challenge not modulate PD outcome. PD+AL group presented decreased tumour necrosis factor‐ α (TNF‐ α ), interleukin (IL)‐1 β ,interferon‐ γ , IL‐17A, receptor activator of nuclear factor κ ‐light‐chain‐enhancer of activated B cells ligand and matrix metalloproteinase (MMP)‐13 levels in periodontal tissues, while IL‐4 and IL‐10 levels were unaltered by AL co‐induction. AL co‐induction also resulted in upregulated T‐bet and related orphan receptor γ and downregulated GATA3 levels expression in submandibular LNs when compared with PD group. Conclusion: Our results demonstrate that the interaction between experimental periodontitis and allergy involves functional immunological interferences, which restrains experimental periodontitis development by means of a skewed immune response.