Premium
Gingival overgrowth in subjects under immunosuppressive regimens based on cyclosporine, tacrolimus, or sirolimus
Author(s) -
Cota Luís Otávio Miranda,
Aquino Davi Romeiro,
Franco Gilson César Nobre,
Cortelli José Roberto,
Cortelli Sheila Cavalca,
Costa Fernando Oliveira
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01601.x
Subject(s) - medicine , tacrolimus , tannerella forsythia , sirolimus , ciclosporin , gastroenterology , post hoc analysis , transplantation , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Cota LOM, Aquino DR, Franco GCN, Cortelli JR, Cortelli SC, Costa FO. Gingival overgrowth in subjects under immunosuppressive regimens based on cyclosporine, tacrolimus, or sirolimus. J Clin Periodontol 2010; 37: 894–902. doi: 10.1111/j.1600‐051X.2010.01601.x. Abstract Aim: To assess the prevalence and variables associated with gingival overgrowth (GO) in renal transplant recipients medicated with cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir). Materials and Methods: One hundred and thirty‐five eligible subjects were divided in CsA, Tcr, and Sir groups comprising 45 subjects each. GO was visually assessed and subjects were assigned as GO+ or GO− in a post hoc definition. Saliva samples were collected and the presence of periodontal pathogens was assessed through polymerase chain reaction. Variables of interest were compared between GO+ and GO− subjects through univariate and multivariate analysis. Results: Prevalence of GO was of 60.0% for CsA, 28.9% for Tcr, and 15.6% for Sir groups. Within the CsA group, GO was associated with papillary bleeding index ( p =0.001); within the Tcr group, GO was associated with CsA previous use ( p =0.013), and calcium channel blockers (CCB) use ( p =0.003); within the Sir group, GO was associated with papillary bleeding index ( p =0.018), and CCB use ( p =0.020). A higher frequency of Tannerella forsythia was observed among GO+ subjects medicated with Tcr. Conclusion: Pharmacological and periodontal variables were associated with GO in different immunosuppressive regimens. Integration between the medical and the dental team may be an important approach in the post‐transplant maintenance routine.