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A double‐blind randomized‐controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice
Author(s) -
Orsini Giovanna,
Procaccini Maurizio,
Manzoli Lamberto,
Giuliodori Francesca,
Lorenzini Alessandro,
Putignano Angelo
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01558.x
Subject(s) - dentifrice , dentistry , potassium nitrate , medicine , randomized controlled trial , sodium fluoride , fluoride , potassium , chemistry , surgery , inorganic chemistry , organic chemistry
Orsini G, Procaccini M, Manzoli L, Giuliodori F, Lorenzini A, Putignano A. A double‐blind randomized‐controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. J Clin Periodontol 2010; 37: 510–517. doi: 10.1111/j.1600‐051X.2010.01558.x. Abstract Background and Aim: Several dentifrices have shown to be effective in reducing dentine hypersensitivity (DH), but more effective products are needed. The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc–carbonate hydroxyapatite (CHA) nanocrystals. Methods and Materials: Using a double‐blind, randomized design, the new dentifrice was compared with potassium nitrate/fluoride dentifrice (active control). The participant's DH was evaluated at baseline and after 4 and 8 weeks using airblast (primary outcome), tactile, cold water and subjective tests (secondary outcomes). Results: The final sample consisted of 70 subjects with baseline DH; 36 received the new dentifrice and 34 the control one. Both dentifrices were largely effective; the percentage of score reduction from baseline to 8 weeks was greater than 28% for all tests (and greater than 55% for the cold water test) in both groups. As compared with controls, experimental subjects had a significantly greater improvement in the airblast test score (mean percentage of reduction of 46.0% versus 29.4% in controls) and the subjective test score (47.5% versus 28.1%, respectively), with both differences already being significant after 4 weeks. In contrast, there was no significant difference between groups for either the tactile or cold water tests at any time point and with any outcome. Conclusions: This study documented that the new dentifrice containing zinc–CHA nanocrystals significantly reduced dentinal hypersensitivity after 4 and 8 weeks, supporting its utility in clinical practice.