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Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs
Author(s) -
Schwarz Frank,
Jung Ronald E.,
Fienitz Tim,
Wieland Marco,
Becker Jürgen,
Sager Martin
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01551.x
Subject(s) - osseointegration , dentistry , implant , regeneration (biology) , wound healing , titanium , bone healing , biomedical engineering , medicine , materials science , surgery , metallurgy , biology , microbiology and biotechnology
Schwarz F, Jung RE, Fienitz T, Wieland M, Becker J, Sager M. Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs. J Clin Peridontol 2010; 37: 474–485. doi: 10.1111/j.1600‐051X.2010.01551.x. Abstract Objectives: The aim of the present study was to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces (modSLA). Materials and Methods: ModSLA implants were placed at chronic‐type lateral ridge defects of different heights (H1–H4: 2, 4, 6 and 8 mm) and randomly allocated to either (a) GBR (polyethylene glycol membrane + biphasic calcium phosphate) or (b) untreated control. At 2 and 8 weeks ( n =6 dogs each), dissected blocks were processed for histomorphometrical analysis [e.g., percentage linear fill (PLF), regenerated area (RA)]. Results: At 8 weeks, both groups revealed comparable mean PLF (%) [Control: H1 (26.1 ± 5.8)–H4 (60.4 ± 11.8); GBR: H1 (8.3 ± 5.3)–H4 (50.7 ± 23.1)] and RA (mm 2 ) [Control: H1 (2.5 ± 0.4)–H4 (7.4 ± 4.1); GBR: H1 (1.8 ± 1.0)–H4 (10.8 ± 5.9)] values. A significant difference was observed for the mean PLF values at H1 defects. Conclusion: It was concluded that (i) modSLA titanium implants supported bone regeneration and osseointegration at H1–H4 defects and (ii) the present GBR procedure did not seem to improve the outcome of vertical bone regeneration, but tended to increase the mean RA values.