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Regenerative effect of basic fibroblast growth factor on periodontal healing in two‐wall intrabony defects in dogs
Author(s) -
Shirakata Yoshinori,
Taniyama Katsuyoshi,
Yoshimoto Takehiko,
Miyamoto Motoharu,
Takeuchi Naoshi,
Matsuyama Takashi,
Noguchi Kazuyuki
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2010.01539.x
Subject(s) - enamel matrix derivative , basic fibroblast growth factor , cementum , periodontal fiber , beagle , dentistry , medicine , junctional epithelium , platelet derived growth factor receptor , growth factor , platelet derived growth factor , regeneration (biology) , pathology , connective tissue , dentin , biology , receptor , microbiology and biotechnology
Shirakata Y, Taniyama K, Yoshimoto T, Miyamoto M, Takeuchi N, Matsuyama T, Noguchi K. Regenerative effect of basic fibroblast growth factor on periodontal healing in two‐wall intrabony defects in dogs. J Clin Periodontol 2010; 37: 374–381. doi: 10.1111/j.1600‐051X.2010.01539.x. Abstract Aim: The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two‐wall intrabony defects in dogs. Materials and Methods: Two‐wall intrabony defects (5 × 5 × 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet‐derived growth factor with β ‐tricalcium phosphate (PDGF/ β ‐TCP) treatments, and sham‐surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/ β ‐TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks. Results: Bone formation was significantly greater in the bFGF group (4.11 ± 0.77 mm) than in the EMD (3.32 ± 0.71 mm; p <0.05) and OFD (3.09 ± 0.52 mm; p <0.01) groups. The EMD (4.59 ± 1.19 mm) and PDGF/ β ‐TCP (4.66 ± 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament‐like tissue than the OFD group (2.96 ± 0.69 mm; p <0.01). No significant differences were observed between the bFGF and the PDGF/ β ‐TCP groups in any of the histometric parameters. Conclusions: The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/ β ‐TCP.