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Fc γ receptor polymorphisms and their association with periodontal disease: a meta‐analysis
Author(s) -
Dimou Niki L.,
Nikolopoulos Georgios K.,
Hamodrakas Stavros J.,
Bagos Pantelis G.
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01530.x
Subject(s) - odds ratio , meta analysis , aggressive periodontitis , allele , genotype , confidence interval , chronic periodontitis , periodontitis , periodontal disease , medicine , polymorphism (computer science) , gastroenterology , immunology , genetics , biology , gene
Dimou NL, Nikolopoulos GK, Hamodrakas SJ, Bagos PG. Fc γ receptor polymorphisms and their association with periodontal disease: a meta‐analysis. J Clin Periodontol 2010. 37: 255–265 doi: 10.1111/j.1600‐051X.2009.01530.x. Abstract Aim: A systematic review and a meta‐analysis were conducted in order to investigate the potential association of Fc γ receptor (Fc γ R) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials and Methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta‐analysis: Fc γ RIIA H131R (rs1801274), Fc γ RIIIA F158V (rs396991) and Fc γ RIIIB NA1/NA2. Random‐effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The Fc γ RIIIB NA1/NA2 polymorphism was associated with both aggressive (per‐allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the Fc γ RIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between Fc γ RIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between Fc γ RIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene–gene or gene–environment interactions (i.e. with smoking).