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Growth/differentiation factor‐5: a candidate therapeutic agent for periodontal regeneration? A review of pre‐clinical data
Author(s) -
Moore Yolanda R.,
Dickinson Douglas P.,
Wikesjö Ulf M. E.
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01527.x
Subject(s) - medicine , periodontal fiber , bone healing , regeneration (biology) , cartilage , craniofacial , growth differentiation factor , bone morphogenetic protein , bioinformatics , dentistry , pathology , surgery , biology , anatomy , psychiatry , gene , microbiology and biotechnology , biochemistry
Moore YR, Dickinson DP, Wikesjö UME. Growth/differentiation factor‐5: a candidate therapeutic agent for periodontal regeneration? A review of pre‐clinical data. J Clin Periodontol 2010; 37: 288–298. doi: 10.1111/j.1600‐051X.2009.01527.x. Abstract Aim: Therapeutic concepts involving the application of matrix, growth and differentiation factors have been advocated in support of periodontal wound healing/regeneration. Growth/differentiation factor‐5 (GDF‐5), a member of the bone morphogenetic protein family, represents one such factor. The purpose of this review is to provide a background of the therapeutic effects of GDF‐5 expressed in various musculoskeletal settings using small and large animal platforms. Methods: A comprehensive literature search was conducted to identify all reports in the English language evaluating GDF‐5 using the PubMed and Google search engines, and a manual search of the reference lists from the electronically retrieved reports. Two reviewers independently screened the titles and abstracts from a total of 69 reports, 22 of which were identified as pre‐clinical (in vivo) evaluations of GDF‐5. The full‐length article of the 22 pre‐clinical reports was then reviewed. Results: Various applications including cranial and craniofacial bone formation, spine fusion, long bone fracture healing, cartilage, and tendon/ligament repair using a variety of small and large animal platforms evaluating GDF‐5 as a therapeutic agent were identified. A majority of studies, using biomechanical, radiographic, and histological analysis, demonstrated significant dose‐dependent effects of GDF‐5. These include increased/enhanced local bone formation, fracture healing/repair, and cartilage and tendon/ligament formation. GDF‐5 frequently was shown to accelerate wound maturation. Several studies demonstrated GDF‐5 to be a realistic alternative to autograft bone. Studies using pre‐clinical models and human histology suggest GDF‐5 may also increase/enhance periodontal wound healing/regeneration. Conclusions: GDF‐5 appears a promising therapeutic agent for periodontal wound healing/regeneration as GDF‐5 supports/accelerates bone and tendon/ligament formation in several musculoskeletal settings including periodontal tissues.