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Regenerative treatment with platelet‐rich plasma combined with a bovine‐derived xenograft in smokers and non‐smokers: 12‐month clinical and radiographic results
Author(s) -
Yilmaz Selcuk,
Cakar Gokser,
Ipci Sebnem Dirikan,
Kuru Bahar,
Yildirim Burak
Publication year - 2010
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01509.x
Subject(s) - medicine , dentistry , radiography , gingival recession , soft tissue , chronic periodontitis , platelet rich plasma , gingival sulcus , periodontitis , clinical study , urology , platelet , surgery
Aim: The purpose of this study was to assess the healing response of intrabony defects following regenerative treatment with platelet‐rich plasma (PRP) combined with a bovine‐derived xenograft (BDX) in smokers and non‐smokers. Materials and Methods: A total of 24 advanced chronic periodontitis patients, 12 smokers and 12 non‐smokers, with 113 intrabony defects with an intrabony component of 3 mm were included in this study. Defects were surgically treated with PRP/BDX. At baseline and 12 months after surgery, the following parameters were recorded: plaque and sulcus bleeding indices, probing depth (PD), relative attachment level, marginal recession, probing and radiographic bone levels. Results: Considering the soft tissue measurements, smokers and non‐smokers presented a mean PD reduction of 3.97 ± 0.76 and 4.63 ± 0.52 mm, recession of 0.76 ± 0.44 and 0.50 ± 0.12 mm and attachment gain of 3.26 ± 0.42 and 4.06 ± 0.40 mm, respectively. Evaluation of the hard tissue findings revealed that the mean clinical and radiographic bone gains in smokers and non‐smokers were 2.83 ± 0.47 and 3.63 ± 0.38 mm, 2.98 ± 0.38 and 3.67 ± 0.48 mm, respectively. Inter‐group differences for PD reduction ( p <0.05), attachment ( p <0.001), clinical ( p <0.001) and radiographic bone gains ( p <0.001) were found to be significant between smokers and non‐smokers. Conclusions: Within the limits of this study, the results indicate that treatment outcome following PRP/BDX application in intrabony defects is impaired with smoking.