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Salivary interleukin‐1 β concentration and the presence of multiple pathogens in periodontitis
Author(s) -
Gursoy Ulvi Kahraman,
Könönen Eija,
Uitto VeilJukka,
Pussinen Pirkko J.,
Hyvärinen Kati,
SuominenTaipale Liisa,
Knuuttila Matti
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01480.x
Subject(s) - treponema denticola , tannerella forsythia , aggregatibacter actinomycetemcomitans , periodontitis , prevotella intermedia , saliva , porphyromonas gingivalis , medicine , chronic periodontitis , interleukin , immunology , microbiology and biotechnology , dentistry , biology , cytokine , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Aim: This study aimed to find salivary enzymes and/or cytokines that would reflect periodontitis, alone or in combination with salivary microbial markers. Material and Methods: The salivary concentrations of elastase, lactate dehydrogenase, interleukin‐1 β (IL‐1 β ), interleukin‐6, and tumour necrosis factor‐ α , and the presence of five periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia , and Treponema denticola , were analysed from salivary specimens of 165 subjects, a subpopulation of Health 2000 Health Examination Survey in Finland; 84 of the subjects had probing pocket depth (PPD) of 4 mm at 14 or more teeth (the advanced periodontitis group), while 81 subjects had no teeth with PPD of 4 mm (the control group). All subjects had at least 20 teeth and no systemic diseases. Results: Among the salivary cytokines and enzymes tested, IL‐1 β was the only biomarker associated with periodontitis. An association was also found with the presence of multiple periodontal pathogens. Salivary IL‐1 β and the presence of multiple periodontal pathogens were associated with periodontitis at the same magnitude, when they were in the logistic regression model individually or together. Conclusion: We suggest that salivary IL‐1 β and the presence of multiple periodontal pathogens in saliva should be studied more thoroughly as markers of periodontitis.