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Increased bone formation around coated implants
Author(s) -
Stadlinger Bernd,
Bierbaum Susanne,
Grimmer Silke,
Schulz Matthias C.,
Kuhlisch Eberhard,
Scharnweber Dieter,
Eckelt Uwe,
Mai Ronald
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01435.x
Subject(s) - resonance frequency analysis , implant , dentistry , endosseous implants , osseointegration , medicine , surgery
Aim: We hypothesized that coating threaded, sandblasted acid‐etched titanium implants with collagen and chondroitin sulphate (CS) increases bone formation and implant stability, compared with uncoated controls. Materials and Methods: Three different implant surface conditions were applied: (1) sandblasted acid‐etched (control), (2) collagen/chondroitin sulphate (low‐dose – CS1), (3) collagen/chondroitin sulphate (high‐dose – CS2). Sixty 9.5 mm experimental implants were placed in the mandible of 20 minipigs. Bone–implant contact (BIC) and relative peri‐implant bone‐volume density (rBVD – relation to bone‐volume density of the host bone) were assessed after 1 and 2 months of submerged healing. Implant stability was measured by resonance frequency analysis (RFA). Results: After 1 month, coated implants had significantly more BIC compared with controls (CS1: 68%, p <0.0001, CS2: 63%, p =0.009, control: 52%). The rBVD was lower for all surface conditions, compared with the hostbone. After 2 months, BIC increased for all surfaces. No significant differences were measured (CS1: 71%, p =0.016, CS2: 68%, p =0.67, control: 63%). The rBVD was increased for coated implants. RFA values were 71–77 at implantation, 67–73 after 1 month and 74–75 after 2 months. Differences in rBVD and RFA were not statistically significant. Conclusions: Data analysis suggests that collagen/CS has a positive influence on bone formation after 1 month of endosseous healing.