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One‐year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof‐of‐principle randomized‐controlled clinical trial
Author(s) -
Lulic Martina,
Leiggener Görög Isabelle,
Salvi Giovanni E.,
Ramseier Christoph A.,
Mattheos Nikolaos,
Lang Niklaus P.
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01432.x
Subject(s) - medicine , bleeding on probing , debridement (dental) , photodynamic therapy , randomized controlled trial , maintenance therapy , dentistry , gingival and periodontal pocket , clinical trial , surgery , periodontitis , chemotherapy , chemistry , organic chemistry
Background: Single photodynamic therapy (PDT) has been effective in initial periodontal therapy, but only improved bleeding on probing (BoP) in maintenance patients after a single use. Repeated PDT has not been addressed. Objectives: To study the possible added benefits of repeated adjunctive PDT to conventional treatment of residual pockets in patients enrolled in periodontal maintenance. Material and Methods: Ten maintenance patients with 70 residual pockets [probing pocket depth (PPD)5 mm] were randomly assigned for treatment five times in 2 weeks (Days 0, 1, 2, 7, 14) with PDT (test) or non‐activated laser (control) following debridement. The primary outcome variable was PPD, and the secondary variables were clinical attachment level (CAL) and BoP. These were assessed at 3, 6 and 12 months following the interventions. Results: Greater PPD reductions were observed in the test (−0.67 ± 0.34; p =0.01) compared with the control patients (−0.04 ± 0.33; NS) after 6 months. Significant CAL gain (+0.52 ± 0.31; p =0.01) was noted for the test, but not in the control (−0.27 ± 0.52; NS) patients after 6 months. BoP percentages dcreased significantly in test (97–64%, 67%, 77%), but not control patients after 3, 6 and 12 months. Conclusions: Repeated (five times) PDT adjunctive to debridement yielded improved clinical outcomes in residual pockets in maintenance patients. The effects were best documented after 6 months.