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Probiotic effects of orally administered Lactobacillus salivarius WB21‐containing tablets on periodontopathic bacteria: a double‐blinded, placebo‐controlled, randomized clinical trial
Author(s) -
Mayanagi Gen,
Kimura Moto,
Nakaya Seigo,
Hirata Haruhisa,
Sakamoto Mitsuo,
Benno Yoshimi,
Shimauchi Hidetoshi
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2009.01392.x
Subject(s) - tannerella forsythia , placebo , lactobacillus salivarius , medicine , probiotic , periodontitis , dental plaque , chronic periodontitis , odds ratio , population , bleeding on probing , lactobacillus , gastroenterology , dentistry , bacteria , biology , pathology , honeysuckle , alternative medicine , environmental health , traditional chinese medicine , genetics
Aim: This study was designed to evaluate whether the oral administration of lactobacilli could change the bacterial population in supra/subgingival plaque. Material and Methods: Sixty‐six healthy volunteers without severe periodontitis were randomized into two groups to receive lactobacilli or placebo for 8 weeks (8W): the test group ( n =34) received 2.01 × 10 9 CFU/day of Lactobacillus salivarius WB21 and xylitol in tablets; the control group ( n =32) received placebo with xylitol. Supra/subgingival plaque samples were collected at the baseline and after 4 weeks (4W) and 8W. The bacterial amounts in plaque samples were analysed by quantitative real‐time polymerase chain reaction. Results: The numerical sum of five selected periodontopathic bacteria in the test group was decreased significantly in subgingival plaque at 4W [odds ratio (OR)=3.13, 95% confidence intervals (CI)=1.28–7.65, p =0.012]. Multivariate analysis showed that significantly higher odds were obtained for the reduction of Tannerella forsythia in subgingival plaque of the test group at both 4W (OR=6.69, 95% CI=2.51–17.9, p <0.001) and 8W (OR=3.67, 95% CI=1.45–9.26, p =0.006). Conclusion: Oral administration of probiotic lactobacilli reduced the numerical sum of five selected periodontopathic bacteria and could contribute to the beneficial effects on periodontal conditions.