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Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus
Author(s) -
Matsumoto Sayaka,
Ogawa Hiroshi,
Soda Satoshi,
Hirayama Satoshi,
Amarasejith,
Aizawa Yoshifusa,
Miyazaki Hideo
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01359.x
Subject(s) - adiponectin , medicine , type 2 diabetes mellitus , insulin resistance , diabetes mellitus , gastroenterology , dentistry , insulin , endocrinology
Aims: The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustained by periodontal maintenance (PM). Material and Methods: Twenty‐seven T2DM patients were randomly assigned into test or control groups. Test received scaling with ultrasonic devices at baseline and APT biweekly for 2 months while control received scaling at baseline and mechanical tooth cleaning (MPT) at the same interval. At 6 months, all patients received mechanical tooth cleaning as PM. Periodontal examination and blood measurements were performed at baseline, 4 and 9 months. Results: Adiponectin concentrations in test had significantly increased by 31.4% after APT ( p =0.024) and by 30.4% after PM ( p =0.002) compared with baseline. The percentage of 4 mm probing depths (PD) had shown 8.3% and 9.3% reduction after APT and PM ( p =0.046, 0.02) in test while 5.0% reduction after MPT in control group ( p =0.031). Conclusions: Our results suggested that APT and PM not only improve periodontal disease but also increase serum adiponectin in T2DM patients.