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Treatment of experimental periodontal disease by photodynamic therapy in immunosuppressed rats
Author(s) -
Fernandes Leandro Araújo,
De Almeida Juliano Milanezi,
Theodoro Leticia Helena,
Bosco Alvaro Francisco,
Nagata Maria José Hitomi,
Martins Thiago Marchi,
Okamoto Tetuo,
Garcia Valdir Gouveia
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01355.x
Subject(s) - ligature , scaling and root planing , dexamethasone , medicine , photodynamic therapy , saline , adjunctive treatment , periodontitis , dentistry , periodontal disease , molar , chronic periodontitis , chemistry , organic chemistry
Background and Objective: The aim of this study was to compare photodynamic therapy (PDT) as an adjunctive treatment of induced periodontitis with scaling and root planing (SRP) in dexamethasone‐inhibited rats. Material and Methods: The animals were divided into two groups: ND ( n =90), saline solution treatment; D ( n =90), dexamethasone treatment. In the ND and D Groups, periodontal disease was ligature‐induced at the first mandibular molar. After 7 days, the ligature was removed and all animals received SRP and were divided according to the following treatments: SRP, saline solution; Toluidine Blue‐O (TBO), phenothiazinium dye; and PDT, TBO and laser irradiation. Ten animals in each treatment were killed at 7, 15 and 30 days. The radiographic and histometric values were statistically analysed. Results: In the ND and D Groups, radiographic analysis showed less bone loss in animals treated by PDT in all the experimental periods than SRP and TBO at 15 days ( p <0.05). After a histometric analysis was carried out in the ND and D groups, the animals treated by PDT showed less bone loss in all periods than SRP and TBO after 15 days ( p <0.05). Conclusions: The PDT was an effective adjunctive treatment of induced periodontitis compared with SRP in dexamethasone‐inhibited rats.