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New directions in host modulation for the management of periodontal disease
Author(s) -
Bhatavadekar Neel B.,
Williams Ray C.
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01354.x
Subject(s) - disease , inflammation , medicine , periodontal disease , periodontitis , intensive care medicine , immunology , bioinformatics , dentistry , pathology , biology
Abstract Background: New strategies for periodontal disease management have been emerging as more is learned about the role of the host response. Our increasing understanding of inflammation and its resolution has opened the door to the study of new periodontal treatment strategies. This commentary examines periodontal disease in light of a new understanding of the role of inflammation in disease expression, thus setting the stage for the development of new prevention and treatment strategies of a widespread disease. Methods: We examined current publications and focused on articles relating to anti‐inflammatory and pro‐resolution mechanisms in periodontal disease. Results: Recent research has examined the inflammatory and resolution cascade in greater detail while looking at endogenous and exogenous mediators that can be utilized to achieve therapeutic end‐points. The possible introduction of “resolution indices” for drug testing warrants a new look at pharmacologic agents that might have been overlooked for their beneficial effects in periodontal disease treatment. Conclusion: The emerging awareness of inflammation and its control in periodontal disease management underscores the importance of exploring inflammatory pathways and mediators, thus exploring new ways to control inflammation. This direction of research promises a new era in drug discovery and therapeutics for periodontal disease treatment.