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IL‐6 −174 genotype associated with the extent of periodontal disease in type 1 diabetic subjects
Author(s) -
Raunio Taina,
Knuuttila Matti,
Hiltunen Liisa,
Karttunen Riitta,
Vainio Olli,
Tervonen Tellervo
Publication year - 2009
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01344.x
Subject(s) - genotype , medicine , bleeding on probing , periodontal disease , gastroenterology , glycemic , type 2 diabetes , diabetes mellitus , disease , type 2 diabetes mellitus , chronic periodontitis , periodontitis , polymorphism (computer science) , endocrinology , gene , biology , genetics
Aim: The aim of this study was to investigate whether genetic polymorphism in certain cytokine and receptor molecule genes and diabetic status associate with the extent of periodontal disease in type 1 diabetes mellitus (DM). Material and Methods: Eighty patients with type 1 DM participated. Visible plaque, bleeding on probing (BOP), probing pocket depth (PD) and attachment level (AL) were examined clinically and glycosylated haemoglobin (HbA1c) levels were used to assess the glycemic control of DM. CD‐14, IL‐6, TNF‐ α , IL‐10, IL‐1 α , IL‐1 β and TLR‐4 gene polymorphisms were studied using the polymerase chain reaction (PCR). Results: The 3‐year HbA1c was good (<7.5%) in 16%, acceptable (7.5–8.5%) in 36% and poor (>8.5%) in 48% of the subjects. IL‐6 −174 genotype and 3‐year GHbA1c associated significantly with BOP and PD4 mm, subjects with the GG genotype of the IL‐6 −174 exhibiting more severe periodontal disease than those with the GC/CC genotype. After stratification by IL‐6 genotype, associations between the extent of periodontal disease and 3‐year HbA1c levels remained significant in subjects carrying the GC/CC but not the GG genotype. Conclusions: In addition to the HbA1c level, the IL‐6 −174 genotype is a significant susceptibility factor for periodontal disease among type 1 diabetics.