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TLR4 and IL‐18 gene variants in aggressive periodontitis
Author(s) -
Noack Barbara,
Görgens Heike,
Lorenz Katrin,
Ziegler Andreas,
Hoffmann Thomas,
Schackert Hans Konrad
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01334.x
Subject(s) - genotype , aggressive periodontitis , periodontitis , allele , chronic periodontitis , biology , gene , immunology , genetics , allele frequency , tlr4 , genotype frequency , receptor , medicine
Aim: We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants in the pathogen‐recognition receptor Toll‐like receptor 4 (TLR4) and variants in the promoter region of the pro‐inflammatory cytokine interleukin‐18 (IL‐18). Material and Methods: One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL‐18 promoter (c.−368G>C and c.−838C>A). The genotype and allele frequencies, as well as the frequency of combined genotypes were compared between study groups. Results: There were no statistical differences in genotype and allele frequencies within the four variants between the groups. All study subjects were further classified into carriers and non‐carriers of at least one variant of both genes. The logistic regression analysis adjusted for gender and smoking showed no association between carrier status of at least one variant of both genes and periodontal status (OR=1.41, 95% CI: 0.43–4.70). Conclusions: Our results reject the hypothesis that functionally relevant IL‐18 and TLR4 gene mutations have a major effect on aggressive periodontitis susceptibility alone or in combination.