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Effects of treatment on soluble tumour necrosis factor receptor type 1 and 2 in chronic periodontitis
Author(s) -
IkezawaSuzuki Ikuyo,
Shimada Yasuko,
Tai Hideaki,
Komatsu Yasutaka,
Tanaka Aya,
Yoshie Hiromasa
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01317.x
Subject(s) - medicine , gastroenterology , chronic periodontitis , periodontitis , tumor necrosis factor alpha , necrosis
Aim: We reported that soluble tumour necrosis factor receptor type 2 (sTNFR2)/type 1 (sTNFR1) ratios in gingival crevicular fluid (GCF) decreased as the severity of chronic periodontitis (CP) increased. This study investigated the effects of the periodontal treatment on TNF‐ α , sTNFR1 and R2 in GCF and serum of CP patients. Material and Methods: Thirty‐five serum and 90 GCF samples were obtained from 35 CP patients (23 non‐smokers and 12 smokers) at baseline and after treatment. The levels of TNF‐ α , sTNFR1 and R2 in serum and GCF were quantified by enzyme‐linked immunosorbant assay. Results: No significant differences were found in the serum levels of TNF‐ α , sTNFR1 and R2 and the ratio of sTNFR2/R1 between baseline and after treatment. After treatment, sTNFR1 and R2 levels in GCF of non‐smokers and smokers were significantly decreased compared with baseline. However, the sTNFR2/R1 ratio was significantly increased (non‐smoker: 0.56±0.03–0.84±0.03, p <0.0001; smoker: 0.59±0.06–0.85±0.04, p =0.0019). There were no significant differences between non‐smoking and smoking CP groups in serum and GCF. Conclusion: The ratio of sTNFR2/R1 in GCF significantly increased after treatment, and could be related to the clinical state of CP.