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Changes in serum interleukin‐6, C‐reactive protein and thrombomodulin levels under periodontal ultrasonic debridement
Author(s) -
Ushida Yuka,
Koshy Geena,
Kawashima Yoko,
Kiji Makoto,
Umeda Makoto,
Nitta Hiroshi,
Nagasawa Toshiyuki,
Ishikawa Isao,
Izumi Yuichi
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01316.x
Subject(s) - thrombomodulin , medicine , debridement (dental) , c reactive protein , periodontal disease , gingival and periodontal pocket , ultrasonic sensor , periodontitis , immunology , dentistry , inflammation , thrombin , platelet , radiology
Aim: This study aimed to compare the effect of single‐visit full‐mouth mechanical debridement (FMD) and quadrant‐wise mechanical debridement (QMD) on the levels of serum interleukin (IL)‐6, C‐reactive protein (CRP) and soluble thrombomodulin. Material and Methods: Thirty‐six subjects with chronic periodontitis were randomly allocated to three groups: undergoing QMD, single‐visit FMD with povidone iodine or with water. Serum IL‐6 and soluble thrombomodulin were measured by enzyme‐linked immunosorbent assay, and serum CRP was measured by the latex‐enhanced nephelometric method. Results: Serum IL‐6 level increased significantly immediately after debridement in all the three groups, with this increase being greatest in the full‐mouth groups. However, the increase in the full‐mouth groups was not significantly higher than that of quadrant‐wise group. In the quadrant‐wise group, serum IL‐6 level decreased significantly 1 month after debridement compared with baseline. Serum‐soluble thrombomodulin decreased significantly in the full‐mouth groups but not in the quadrant‐wise group. Changes in CRP level were not significant at baseline or after debridement in all the three groups. Conclusions: FMD increased serum IL‐6 and reduced serum‐soluble thrombomodulin to a greater extent than QMD, suggesting that the former technique has stronger transient effects on systemic vascular endothelial functions than the latter.