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Ten‐year results following treatment of intra‐bony defects with enamel matrix proteins and guided tissue regeneration
Author(s) -
Sculean Anton,
Kiss Alice,
Miliauskaite Asta,
Schwarz Frank,
Arweiler Nicole B.,
Hannig Matthias
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01295.x
Subject(s) - medicine , enamel matrix derivative , nuclear medicine , weight gain , regeneration (biology) , dentistry , surgery , body weight , biology , microbiology and biotechnology
Background: Surgery utilizing an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. Aim: To evaluate the 10‐year results following treatment with EMD, GTR, EMD+GTR, and open flap debridement (OFD). Material and Methods: Thirty‐eight patients out of an initial group of 56 participants were treated with one of the four modalities. Results were evaluated before surgery, at 1 year, and at 10 years. Primary outcome variable was CAL change. Results: Treatment with EMD yielded a mean CAL gain of 3.4±1.0 mm ( p <0.001) and 2.9±1.4 mm ( p <0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2±1.4 ( p <0.001) at 1 year and 2.8±1.2 mm ( p <0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3±1.1 mm ( p <0.001) and 2.9±1.2 mm ( p <0.001) at 1 and 10 years, respectively. Treatment with OFD demonstrated a mean CAL gain of 2.0±1.2 mm ( p <0.01) at 1 year and 1.8±1.1 mm ( p <0.01) at 10 years. Compared with OFD, the three regenerative treatments resulted in statistically significant ( p <0.05) higher CAL gain, at both 1 and 10 years. The CAL change between 1 and 10 years did not present statistically significant differences in any of the four groups. Conclusion: The present results indicate that the clinical outcomes obtained with all four approaches can be maintained over a period of 10 years.