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Interleukin‐11, interleukin‐1 β , interleukin‐12 and the pathogenesis of inflammatory periodontal diseases
Author(s) -
Yücel Özlem Özer,
Berker Ezel,
Gariboğlu Semra,
Otlu Harika
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2008.01212.x
Subject(s) - periodontitis , gingivitis , medicine , pathogenesis , interleukin , chronic periodontitis , cytokine , inflammation , periodontal disease , interleukin 1β , interleukin 6 , gastroenterology , immunology , interleukin 4 , dentistry
Objectives: The balance between pro‐inflammatory and anti‐inflammatory cytokines may be crucial for determining the immunopathology of gingivitis (G) and periodontitis. This study aimed to analyse interleukin‐1 β (IL‐1 β ), IL‐11 and IL‐12 levels in gingival crevicular fluid (GCF) of patients with G and chronic periodontitis (CP). Material and Methods: Fourty subjects including 12 CP, 14 G and 14 controls (C) were enrolled. GCF samples were collected from six maxillary sites per patient and analysed for IL‐1 β , IL‐11 and IL‐12 by an enzyme‐linked immunosorbent assay. Results: Significantly lower concentrations of IL‐11 were detected in CP compared with both G and C groups ( p <0.05). The CP group had a significantly higher total amount of IL‐12 and IL‐1 β compared with the C group ( p <0.05). The IL‐11:IL‐1 β cytokine ratio was higher in both G and C groups compared with the CP group. The IL‐11:IL‐1 β ratio became progressively lower with increasing probing depth ( p <0.01). Conclusions: Our data showed that IL‐11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL‐11 on inflammation, IL‐11 may be an important factor in the therapeutic modulation of periodontal disease.