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Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus
Author(s) -
Corrocher Giovanni,
Di Lorenzo Gabriele,
Martinelli Nicola,
Mansueto Pasquale,
Biasi Domenico,
Nocini Pier Francesco,
Lombardo Giorgio,
Fior Andrea,
Corrocher Roberto,
Bambara Lisa Maria,
Gelio Stefano,
Pacor Maria Luisa
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01191.x
Subject(s) - tacrolimus , medicine , clobetasol propionate , oral lichen planus , dermatology , etiology , lesion , surgery , psoriasis , transplantation
Background: Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity. Objective: We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment for the treatment of OLP. Patients and Methods: A total of 32 patients (20 females and 12 males; all white, Italian origin, mean age of 43.6±18.4 years; 16 patients per treatment group) were treated with tacrolimus or clobetasol ointment for 4 weeks in a randomized, double‐blind, clinical trial. Pain severity, burning sensation, and mucosal lesion extension were assessed using a four‐point scale. Results: At the end of the treatment period, symptom scores were significantly lower in the tacrolimus group than in the clobetasol group. Conclusion: The results of this study suggest that tacrolimus 0.1% ointment is more effective than clobetasol propionate 0.05% ointment in the treatment of OLP. However, other studies are needed to confirm the effectiveness of this treatment before it can be recommended for use in clinical practice.