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Efficacy of two alcohol‐free cetylpyridinium chloride mouthwashes – a randomized double‐blind crossover study
Author(s) -
Rawlinson Andrew,
Pollington Sarah,
Walsh Trevor F.,
Lamb David J.,
Marlow Ian,
Haywood Julia,
Wright Philip
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01187.x
Subject(s) - cetylpyridinium chloride , crossover study , medicine , dentistry , placebo , chemistry , pulmonary surfactant , biochemistry , alternative medicine , pathology
Aim: (1) To determine the plaque inhibition properties of two formulations of alcohol‐free mouthwash [0.1% w/w cetylpyridinium chloride (CPC) (B) and 0.05% w/w CPC (A)] versus a placebo mouthwash (C). (2) To compare the plaque‐inhibiting activity between these two new CPC mouthwashes. Material and Methods: A double‐blind, crossover study with three 1‐week periods was used. Subjects were randomly assigned to one of the following groups. Group 1 ( n =10) received the mouthwashes A, C and B in the periods 1, 2 and 3, respectively, group 2 ( n =11) received the mouthwashes in the order B, A, C, while group 3 ( n =11) received the mouthwashes in the order C, B, A. Mean plaque areas and Quigley & Hein plaque index scores were analysed using anova (analysis of variance). Measurements were made at the start of each period (baseline) and at 16, 24 and 40 h. Results: Mean plaque scores were similar across the groups at baseline. At all time points thereafter, volunteers using mouthwash A or B had significantly lower plaque areas and plaque index scores than those using mouthwash C ( p <0.05), but there were no significant differences between the test formulations. At 16 h, the reduction in plaque area relative to mouthwash C was 22% for mouthwash A and 18% for mouthwash B; at 24 h, 11% for mouthwash A and 15% for mouthwash B; and at 40 h, 15% for mouthwash A and 16% for mouthwash B. Conclusions: The use of both CPC mouthwashes resulted in less plaque accumulation compared with the control. There was no statistically significant difference in plaque accumulation between the two CPC mouthwashes.